Adult stem cells are undifferentiated cells that are found in most animal tissues. Adult stem cells can divide by mitosis throughout their lifespan to form identical stem cells (self-renewal) or to form cells that can differentiate into the functioning cells of that tissue. Telomeres prevent loss of genes. Adult stem cells have chromosomes with long telomeres. Explain why long telomeres are an advantage to cells that carry out many cell cycles. ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . ......................................................................................................................................... Haematopoietic stem cells (HSCs) are adult stem cells that are located in the bone marrow of bones. HSCs have a role in the formation of blood cells. Fig. 4.1 is an outline summary showing the formation of some of the different types of blood cell that can be formed from HSCs. The first stage is the division of HSCs to produce progenitor cells. These cells are also able to divide by mitosis, but are not stem cells. Fig. 4.1
Exam No:9700_w24_qp_22 Year:2024 Question No:4(c)
Answer:

Knowledge points:
5.1.1.1 DNA
5.1.1.2 histone proteins
5.1.1.3 sister chromatids
5.1.1.4 centromere
5.1.1.5 telomeres
5.1.2.1 growth of multicellular organisms
5.1.2.2 replacement of damaged or dead cells
5.1.2.3 repair of tissues by cell replacement
5.1.2.4 asexual reproduction
5.1.3.1 interphase (growth in G1 and G2 phases and DNA replication in S phase)
5.1.3.2 mitosis
5.1.3.3 cytokinesis
5.1.4 outline the role of telomeres in preventing the loss of genes from the ends of chromosomes during DNA replication
5.1.5 outline the role of stem cells in cell replacement and tissue repair by mitosis
5.1.6 explain how uncontrolled cell division can result in the formation of a tumour
Solution:
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