Haemophilia is a group of rare conditions that affects the ability of the blood to clot. These conditions are caused by mutations in the genes coding for factors involved in the blood clotting process. In haemophilia, activation of the blood clotting pathway results in less thrombin being produced than in healthy individuals. Explain how reduced thrombin will affect blood clotting. (3) ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................ ................................................................................................................................................................................................................................................................................

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