Lysozyme is an antibacterial enzyme that was discovered in 1921 by Alexander Fleming, the scientist who discovered penicillin. Lysozyme catalyses the hydrolysis of glycosidic bonds present in peptidoglycan molecules to form smaller products, NAG (N-acetylglucosamine) and NAM ( N -acetylmuramic acid). Before the induced fit hypothesis was proposed in 1958, scientists believed that the lock and key hypothesis explained how lysozyme catalyses the hydrolysis of peptidoglycan to its products. Draw labelled and annotated diagrams in the space provided to show how the lock and key hypothesis was used to explain the mechanism of action of lysozyme on peptidoglycan.

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