N -phenylethanamide, historically used as a painkiller, can be synthesised from benzene as shown. *(c) In the final step of the synthesis, phenylamine reacts with either ethanoyl chloride or ethanoic anhydride. phenylamine + ethanoyl chloride $$\(\rightarrow N\)$$-phenylethanamide + hydrogen chloride phenylamine + ethanoic anhydride $$\(\rightarrow \mathrm{N}\)$$-phenylethanamide + ethanoic acid Ethanoyl chloride is considerably more reactive than ethanoic anhydride. Hazard symbols for reactants and products are shown. Assess the advantages and disadvantages of the use of ethanoic anhydride rather than ethanoyl chloride for this reaction. Consider the hazards associated with the reactants and products, and the atom economy of each reaction. 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Chemistry
IGCSE&ALevel
EDEXCEL
Exam No:wch15-01-que-20240113 Year:2024 Question No:14(c)

Answer:







Knowledge points:

20.Organic Synthesis

Solution:

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