Duchenne muscular dystrophy (DMD) is a genetic disease that is caused by a single gene. DMD affects striated muscle, and symptoms of the disease first appear at an early age. A fibrous protein, dystrophin, stabilises muscle fibres during contraction. A person with DMD produces non-functioning dystrophin or no dystrophin at all. The disease occurs in about four in 100000 people and mainly affects boys. Suggest and explain why boys are more likely to have DMD than girls. ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . ............................................................................................................................................... . .........................................................................................................................................

Biology

IGCSE&ALevel

CAIE

Exam No：9700_m24_qp_42 Year：2024 Question No：10(c)

Answer:

Knowledge points:

2.3.1 describe and draw the general structure of an amino acid and the formation and breakage of a peptide bond

2.3.2 explain the meaning of the terms primary structure, secondary structure, tertiary structure and quaternary structure of proteins

2.3.3.1 hydrophobic interactions

2.3.3.2 hydrogen bonding

2.3.3.3 ionic bonding

2.3.3.4 covalent bonding, including disulfide bonds

2.3.4 state that globular proteins are generally soluble and have physiological roles and fibrous proteins are generally insoluble and have structural roles

2.3.5 describe the structure of a molecule of haemoglobin as an example of a globular protein, including the formation of its quaternary structure from two alpha (α) chains (α–globin), two beta (β) chains (β–globin) and a haem group

2.3.6 relate the structure of haemoglobin to its function, including the importance of iron in the haem group

2.3.7 describe the structure of a molecule of collagen as an example of a fibrous protein, and the arrangement of collagen molecules to form collagen fibres

2.3.8 relate the structures of collagen molecules and collagen fibres to their function

2.4.1 explain how hydrogen bonding occurs between water molecules and relate the properties of water to its roles in living organisms, limited to solvent action, high specific heat capacity and latent heat of vaporisation

Answer:

Knowledge points:

Solution:

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